Influence of different concentrations of Sildenafil Citrate on histological parameters of mice epididymis

Abstract

sildenafil citrate (SC) is widely used for the treatment of erectile dysfunction and maintains a sufficient erection for satisfactory sexual performance. Very limited literatures were published about effects of SC on histological changes of epididymes in human or laboratory animals. The aim of this study was to investigate the influence of different concentrations of SC for different administration periods on some histological parameters of mice epididymes. Seventy five male mice (7-8) weeks old, weighing (23-25)g were used in the present study. The possible effect of SC was tested through the treatment groups of mice with different doses of SC (2, 4, 8, 16)mg/Kg body weight, and for different periods (1, 3, 5) weeks. Histological examination of epididymes were carried out and compared with those belong to untreated group. Results revealed no significant differences (P>0.05) in epididymal weight, tubules diameters and thickness of epithelial layer between treated groups and control group. Conclusion in this study, SC has no effect on epididymis histology