Effect of Citrullus colocynthis on some physiological aspects of female reproductive system in mice as a model for mammals

Abstract

The study was design to investigate the effect of oral administration of Citrullus colocynthis (CC) on some physiological and histological characters of female reproductive organs in mature mice of Swiss albino strain as a model for mammals. The animals were divided into three groups each contains 8 animals. Group one was treated with 6 mg/ Kg body weight BW/ day of alcoholic extract of CC, group two was treated with 9.6 mg/ Kg BW/day of alcoholic extract of CC and group three served as control throughout eight weeks period. The results of the study showed no significant (P>0.05) difference in the ovarian and uterine weight among groups. Significant (P<0.05) differences were shown in ovarian activity in control and group one compared to group two. The number of corpura lutea was highly significant (P<0.01) improved in group one than that of control group. The number of pregnant females was 50% in group one and control group. However the females treated with 6 mg/ Kg BW/ day of alcoholic extract of CC were gave a significant (P<0.01) results in the number of litters when compared with control group. It is concluded from the present research that treating with limiting dose of CC may accelerated the action of ovarian activity and resulted in improvement in the number of litters.