Correlation of positive Bcl-2 expression with some clincopathological parameters in Iraqi colorectal cancer patients

Abstract

Colorectal cancer is an important public health problem in Iraq. It’s considered as the 7th among the commonest 10 cancers by site according to the Iraqi cancer registry. Studying the Bcl-2 expression in colorectal cancer patients is one of the important issue for the prognosis of this tumor. In this study 50 colorectal cancer samples (paraffin embedded sections) were used to detect Bcl-2 expression using Immunohistochemical analysis. The correlation between Bcl-2 expression and site, type and grading was also studied. The results showed that there was a significant difference (P<0.05) in the Bcl-2 expression between cancerous tissue and resection margin while the site, type and grading of the tumor showed generally the opposite data. We concluded that the positive Bcl-2 expression occurred at early stages of carcinogenesis and it’s a voluble prognostic factor and target for therapy.