Clinico-Histological study of Basosquamous Carcinoma of the Skin

Abstract

asosquamous carcinoma is one of skin malignant tumor with features of both basal cell carcinoma and squamous cell carcinoma. It may behave more aggressively with an increased risk of recurrence and metastases. Investigations on the incidence, clinical, histological and immunohistochemical findings of basosquamous cell carcinoma in comparison with basal and squamous cell carcinoma were carried out. The clinical records of 3000 patients were reviewed from Razgary teaching hospital in Erbil from the period of 1-1-2008 to 1-1-2009 for the diagnosis of basosquamous carcinoma, basal and squamous cell carcinoma and an immunohistochemistry study was done to the basosquamous cell carcinoma.The incidence of basosquamous carcinoma is 8.82% among basal 63.24% and squamous cell carcinoma 27.94%. The commonest site is the nose and mostly occurs in patient over 50 years. Regarding immunohistochemical study of both epithelial membrane antigen (EMA) and low molecular weight keratin (LMWK) showed 5 positive cases out of 6 Basosquamous carcinoma cases. It was concluded that Basosquamous carcinoma incidence is less than that of basal and squamous cell carcinoma. The histological diagnosis of basosquamous carcinoma is confirmed by the use of LMWK and EMA immunohistochemical staining of the areas of both basal cell carcinoma area and squamous cell carcinoma area, respectively