Antitumor and Immunomodulatory Activities of Peganum harmala Extracts

Authors

  • Moyassar B. H. Al-shaibani
  • Hiba T. H. Al-mafrachi

DOI:

https://doi.org/10.24126/jobrc.2013.7.1.234

Abstract

This study was designed to search the antitumor potential of Peganum harmala methanolic extracts and to evaluate their role in retardation the immunological side effects pre-and post-treatment which were carried out on 30 Albino male mice and included total and absolute count of leucocytes, micronucleus formation and phagocytic index of peritoneal cells. Our study showed that P. harmala derivatives have considerable antitumor activity with high efficacy in immobilization of the immunological side effects evoked following treatment with antitumor drug. In conclusion, P. harmala possess antitumor activity increases with concentrations increasing. Pre-treatment with these extracts exert higher retardation to the side effects than post-treatment.

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Published

2013-01-01

How to Cite

Al-shaibani, M. B. H. ., & Al-mafrachi, H. T. H. . (2013). Antitumor and Immunomodulatory Activities of Peganum harmala Extracts. Journal of Biotechnology Research Center (JOBRC), 7(1), 11–20. https://doi.org/10.24126/jobrc.2013.7.1.234

Issue

Vol. 7 No. 1 (2013): Issue 1

Section

Research articles

License

This is an Open Access article distributed under the terms of the creative commons Attribution (CC BY) 4.0 license which permits unrestricted use, distribution, and reproduction in any medium or format, and to alter, transform, or build upon the material, including for commercial use, providing the original author is credited.