Evaluation of cellular immune response provoked by experimental infection with Cryptosporidium spp. in mice

Authors

  • Harith S.J. AL-Warid
  • Souhaila H. Mahmood
  • Ihsan M. Alsaqur

DOI:

https://doi.org/10.24126/jobrc.2014.8.1.289

Keywords:

cellular immune, Cryptosporidium

Abstract

Experimental infection was induced in immunosupreesed and non-immunosupressed mice using inoculation of two different Cryptosporidium spp. isolates: faecal origin and river water origin; then the infectivity rate and cellular immunological status were examined in these groups of mice. The results indicated that these two isolates induced experimental infection in immunosuppressed and non-immunosuppressed mice with no significant differences in infectivity rate between groups. Immunosuppressed mice infected with feacal or water origin oocyst showed low and significant values of transformed lymphocytes 8.68% ± 0.65%, 9.18% ± 1.09 respectively and phagocytic index 10.1% ± 1.66 and 11.2% ± 0.19 respectively. It concludes that lymphocyte transformation and phagocytosis index are good indicators to evaluate the cellular immune response in infected experimental mice with Cryptosporidium.

Downloads

Published

2014-01-01

How to Cite

AL-Warid, H. S. ., Mahmood, S. H. ., & Alsaqur, I. M. . (2014). Evaluation of cellular immune response provoked by experimental infection with Cryptosporidium spp. in mice. Journal of Biotechnology Research Center, 8(1), 8–13. https://doi.org/10.24126/jobrc.2014.8.1.289

Issue

Section

Research articles