Influence of hot alcohol extraction of Celery fruits on renal stones dissolution in vitro.

Abstract

This study was carried out to investigate the effect of hot alcohol extraction activity of Apium graveolens fruits on the common Renal stones dissolution (Ca-OX ,Uric acid) kinds and volatile oils concentrations on Apium graveolens via HPLC were estimated. Fourteen compounds which were (α-pinene, Cineole, P- cymene, Terpinene, α- phellandrene, β-pinene, Geraneole, α-terpinole, Linalool, Menthone, Limonene, Myrcene, Camphen, Rutin) were measured. In regard to concentration, α -pinene has the highest concentration since it reaches 19.2 µg/ml, while the lower concentration was achieved with Camphen which was 6.3 µg/ml. Results of Ca-Ox renal stones treated with extract of Apium graveolens showed significant decrease in stone weight since highest weight decrease percentage, using the hot alcoholic extract reaches 17.02 % at 5 % concentration and in comparison with Rowantinex drug, the results showed a high similitude between the hot alcoholic extract at 5% concentration and Rowantinex drug in respect of percentage of renal stones dissolution, so hot alcohol extraction of apium gravedens in 5% concentration was the best and active in dissolution Ca-OX at first degree and uric acid at second degree.