Association Between PTPN22 Gene Polymorphism and Type1 Diabetes in Egyptian Population
DOI:
https://doi.org/10.24126/jobrc.2015.9.2.430Keywords:
Type 1 diabetes, protein tyrosine phosphatase, nonreceptor 22, polymorphismAbstract
The protein tyrosine phosphatase, nonreceptor 22 gene (PTPN22) maps at human chromosome 1p13.3
which encodes an important negative regulator of T-cell activation, lymphoid-specific phosphatase
(Lyp). The PTPN22 gene has been shown to associate with a risk for multiple autoimmune diseases,
including type1 diabetes (T1DM). This study aimed to analyze the association of three PTPN22
polymorphisms in Egyptian population .The single nucleotide polymorphisms (SNP) at positions -1123
(rs#2488457), 1858 (rs#2476601), and +2740 (rs#1217412) were genotyped in 60 persons with T1DM,
and 60 control persons, all three SNPs were genotyping using two technique, allele specific PCR
technique and restriction fragment length polymorphism – PCR (RFLP-PCR). The 1858 C/T did not
show any significance differences between patients and control groups. (
MCP=1.0) whereas, respectively
-1123 G/C and +2740 A/G were significantly associated with T1DM disease (P≤0.0001) and
(P=0.012).These results suggest that the PTPN22 gene of SNPs polymorphisms were associated with
type 1 diabetes in Egyptian population. The difference in the association of the aforementioned SNPs
variants with T1DM among different populations may be attributed to the presence of multiple
susceptibility alleles.
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