Evaluation of Some Biochemical Markers in Patient's with Polycystic Ovarian Syndrome

Abstract

The present study aims to detect several biochemical markers associated with PCOS (Polycystic
ovary syndrome) in Iraqi women comparing the results with control normal fertile women and
also studying the effect of obesity on the same biochemical markers. Ninety eight women with
PCOS, 51 non-obese [body mass index (BMI) less than 25 kg/m2
] and 47 obese (BMI >25 kg/m2
)
were enrolled for the study. Each group of them was compared forty normal fertile women as
control group matched for each in age and BMI. The first part of this study was devoted to the
measurement of Body Mass Index (BMI) and Waist Hip Ratio (WHR), subdivided PCOS
according to the body mass index, and measurement of fasting insulin, fasting glucose,
Homeostatic Model Assessment (HOMA), HbA1c and lipid profile. A significant differences was
found in HbA1c (P≤0.0001) VLDL (p≤0.0001), triglyceride (p≤0.05) and cholesterol (p≤0.05)
between obeses and lean PCOS patients. Insulin serum level (P≤0.0001) was highly significantly
increased in obeses PCOS patients as compared to obeses control, the serum insulin (P≤0.0001)
also significantly increased in lean PCOS women when compared with lean control. There was a
significant differences between HOMA (P≤0.05) in obeses PCOS patients than in the obese
control group and between obese and lean women PCOS patients.