Side Effects of Ribavirin Drug on Mice Embryos and their Skeleton

Abstract

This study focused on the cytogenetic effect of Ribavirin (RBV) drug on teratogenic lab animals
(Mice). Several cytogenetic analyses (skeleton abnormal of embryos in mice). Studied the genetic
effect of drug (RBV) on mice. That mice were divided into five experiment groups as the
following: Negative control group: Animal orally treated with PBS buffer, positive control group
was treated with (CP) and three groups treated with (RBV) with concentration 10, 20, 50 mg/kg,
in other experiment studied teratogens of drug (RBV) result show significant differences (p<0.05)
in body weight of mice embryo of study groups, negative control group recorded rate highly in
embryo body weigh was (1.55) gm. While recorded positive control group rate less in weight of
orally treated groups with (RBV) with concentration 10, 20, 50 mg/kg were 0.89, 0.71, 0.61 gm.
Respectively the result show influences to (RBV) in embryo number at high concentration (50)
mg/kg, while show died embryos in positive control group. Also the result shows abnormality in
skeleton of embryos at concentration of drug 50 mg/kg