The Effect of Acyclovir on Human Lymphocyte Cell Division

Authors

  • اسماء محمود سلمان
  • لمى العبيدي

DOI:

https://doi.org/10.24126/jobrc.2016.10.1.449

Keywords:

Acyclovir, cell division, mitotic index, human lymphocytes

Abstract

Acyclovir is antibiotics commonly used to treat herpes virus infection, which is one of synthetic
nucleosides analogs derived from guanine. This study was aimed to identify the effect of the Acyclovir, as
antiviral drug, on the mitosis in human lymphocytes. Concentrations of acyclovir were prepared 40,
80,120,160, 200 and 240 µg/ml and added to phytohemagglutin in treated culture media. Results showed
that the average of mitotic index, was dropped sharply and significantly at the 40 µg /ml concentration
of Acyclovir to be 14.21 ± 1.48, then the average of mitotic index was increase gradually to reach 60.20
± 1.00, at the 240 µg/ ml concentration. This study indicated that Acyclovir inhibited human lymphocyte
proliferation at low concentrations. Further studies are recommended to study the effect of acyclovir on
the mitotic index on human lymphocytes of infected individuals.

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Published

2016-01-03

How to Cite

سلمان ا. م., & العبيدي ل. (2016). The Effect of Acyclovir on Human Lymphocyte Cell Division. Journal of Biotechnology Research Center, 10(1), 11–14. https://doi.org/10.24126/jobrc.2016.10.1.449

Issue

Vol. 10 No. 1 (2016): issues 1

Section

Research articles

License

This is an Open Access article distributed under the terms of the creative commons Attribution (CC BY) 4.0 license which permits unrestricted use, distribution, and reproduction in any medium or format, and to alter, transform, or build upon the material, including for commercial use, providing the original author is credited.