Physiological and Histological Study for the Effect of Escalation Doses of Dostinex (Caprigoline) on Male Mice through Some Biochemical Parameters

Abstract

Although the history of many drugs proved some beneficial effects, yet uncontrolled use may have serious impact on health especially vital organs as liver and kidney and endocrine glands. Dopamine agonists are the treatment of choice for the majority of patients with hyperprolactinemic disorders. Bromocriptine has been used over the past 30 years, whereas cabergoline has become a first-choice agonist in recent years. The present study was aimed to evaluate the physiological and histological effects of escalated doses of the drug (Caprigoline) in male mice. The experiment includes 40 mice divided on 4 groups. Group 1 treated with PBS represents the control. The groups (2, 3, and 4) treated with the doses (0.5, 5, and 10) mg of caprigoline /Kg body weight respectively. Regarding hormonal assay, the results showed significant (P<0.05) differences between the treated groups and the control. There was a significant increase in luteinizing hormone (LH), testosterone, Triiodothyronine (T3) and Throxine (T4) level accompanies the increase in caprigoline dose. In contrast the Follicle stimulating hormone (FSH) and prolactin (PRL) show a decrease in their levels as the dose become higher. Furthermore; there was a significant increase in level of Alanin aminotransaminase (ALT) as an indicator of liver function and a significant increase in level of urea as an indicator of kidney function in the treated groups compared with the control. The histological study reveal an obvious morphological changes compared with the normal state in the animals treated with the high dose. The liver in mice treated with (5 and 10) mg caprigoline showing focal area of necrosis with inflammatory cells. The kidney in mice treated with 10 mg caprigoline shows a degenerative changes and necrosis of epithelial of micro tubules and thyroidization phenomeno.