Evaluating some biochemical parameters after repeated orally administration of levofloxacin in male rats

Abstract

     This study was conducted to evaluate some biochemical parameters of levofloxacin in male rats. It was carried out on fifty four of the albino male rats, they were divided into three main groups equally and orally dosed levofloxacin and assigned as, the first group was dosed with the therapeutic dose 7.5mg/kg/bw, the second group was dosed with the double therapeutic dose 15mg/kg/bw, the third group was dosed with distilled water (negative control). The three groups were divided into three subgroups equally according to dosing period of 2 weeks, 4 weeks, 1 week after discontinuation of dosing. The results showed, there were significant P<0.05 increases in creatine kinase myocardial band of group 1 after 4 weeks of treatment and 1 week of levofloxacin withdrawal in comparison with control group, also there were significant P<0.05 increases in troponin-t of group 2 after 1 week of levofloxacin withdrawal in comparison with control group. While aspartate aminotransferase, total plasma protein, and creatinine levels showed significant P<0.05 increases and significant P<0.05 decreases in total plasma bilirubin level, but within normal limits, between experimental groups and control group. Whereas, there were no significant P>0.05 changes in blood urea nitrogen levels between the experimental groups. We concluded that levofloxacin revealed minor toxic effects on organs tissue and most of these effects were reversible.