Chromosomal abnormalities associated with male infertility in Baghdad Iraq

Authors

  • Saad M. Nada
  • Hazim I. Al-Ahmed
  • hussien Obade

DOI:

https://doi.org/10.24126/jobrc.2018.12.1.543

Keywords:

male infertility, cytogenetic, abnormal chromosom

Abstract

In the current study, 142 patients (109 azoospermia and 33 severoligospermia) were studied in order to explore the cytogenetic cause’s background and the hormonal study of male infertility in Baghdad Strip of Iraq. Of the 142 infertile males,14 patients showed abnormal chromosomal karyotypes corresponding to a frequency of  9.85% (14/142), the occurrence of chromosomal abnormalities was only confined to the azoospermia patient group. Patients with abnormal karyotypes represented 12.84% (14/109) of the azoospermia patients. Nine had a 47, XXY karyotype of Klinefelter's syndrome [47XY;64.28% (9/14)], [47XY+mar;14.28% (2/14)], [46XY,del13(p12) and (del21(p12);7.14% (1/14)], [46XY,tra(5;12, -6); 7.14% (1/14)] and one with chromosomal instability that showed multiple mosaic karyotypes 7.14% (1/14). The hormonal levels of nine patients with Klinefelter's syndrome (KFS) were diagnosed in the present study, and the results showed elevated FSH and LH concentrations compared with control. While serum testosterone values were below the control.

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Published

2018-01-01

How to Cite

Nada, S. M. ., Al-Ahmed, H. I., & Obade, hussien. (2018). Chromosomal abnormalities associated with male infertility in Baghdad Iraq. Journal of Biotechnology Research Center (JOBRC), 12(1), 7–13. https://doi.org/10.24126/jobrc.2018.12.1.543

Issue

Section

Research articles