Polymorphism of P-selectin (- 2123C/G, rs1800807 C/G) and IL-4 -1098 in a sample of Iraqi Diabetes Mellitus Type 2

Abstract

Diabetes is a major public health problem because it is world’s sixth cause of death. An inflammatory disease that associated with many inflammatory markers, which is a key for complications of vascular endothelial system, literally for high risk populations. Some adhesion molecules were studied in the sera of Iraqi Arab female as P-selectin associated with inflammatory disease and Cytokines. This work tend to evaluate the association between soluble P-selectin level, polymorphism for mutation site 2123C/G (rs1800807) and the role of P-selectin and IL-4  polymorphism in the developing of  Diabetes Mellitus type 2. Genetic polymorphism of P-selectin gene was investigated at the position -2123C/G, Present study illustrated three genotypes (GG, GC, CC), with the significant protective effect for G allele and Etiological effect for C allele. The Polymorphism of IL-4- gene at the position IL-4 -1098 was presented with three genotypes (TT, TC and CC), Furthermore the result of C allele frequency (RR=1.45 with EF=0.312) reflect an Etiological effect for C allele with positive association with disease. All present factors in the first view  may occur as  independent risk factors but after a deeply focusing on results, it seems as if there’s a sequence functions among them, the result in a synergist effect  interfere with Diabetes Mellitus type 2