The Correlation between Vitamin D and Clinical Implications for Obesity-Related Type 2 Diabetes Mellitus

Authors

  • Noor Thair Tahir
  • Hind SH. Ahmed
  • Rasha K. Hashim
  • Teba D. Soluiman

DOI:

https://doi.org/10.24126/jobrc.2020.14.1.587

Keywords:

Diabetes Mellitus, Obesity, Insulin Resistance, Vitamin D3

Abstract

Background: Obesity and type 2 diabetes have both rapidly raised during the last periods and are ongoing to increase at a disturbing rate universal. Several clinical and epidemiological researches demonstrated a reverse association between circulating vitamin D levels, central adiposity and the progress of insulin resistance and diabetes.

Objective: The target of this work was to elucidate the complex role of vitamin D and the clinical implications of diabetes on metabolic defects related with obesity.

Subjects and Methods: This study encompassed 90 diabetic patients (45 obese and 45 non obese) who were attending the National Diabetic Center/ Al-Mustansiriyah University during the period from June 2019 to January 2020; their age range was (35-60) years. All participant underwent clinical and biochemical examinations.

Results: A substantial rise (p= 0.01) in waist/hip ratio, body mass index, fasting serum glucose, total cholesterol, triacylglycerol, and low density lipoprotein cholesterol in obese diabetic patients as paralleled to non-obese group. Moreover, there was an elevation in glycated hemoglobin, serum insulin, and homeostasis model assessment for insulin resistance in obese group, but it was not significant. A substantial decrease (p= 0.01) in serum high density lipoprotein cholesterol and vitamin D3 were detected in obese diabetic patients as paralleled to non-obese group.      

Also, obese diabetic patients had the higher percent (61%) of D3 deficiency as paralleled to non-obese patients.

Conclusions: In the present study, it is found that there is significant increase in blood sugar in the individuals with decreased vitamin D levels, which was related with insulin resistance, decreased β-cell function, and obesity.

 

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Published

2020-12-15

How to Cite

Tahir, N. T., Ahmed, H. S., Hashim, R. K., & Soluiman, T. D. (2020). The Correlation between Vitamin D and Clinical Implications for Obesity-Related Type 2 Diabetes Mellitus. Journal of Biotechnology Research Center (JOBRC), 14(1), 39–45. https://doi.org/10.24126/jobrc.2020.14.1.587

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Section

Research articles