Correlation between Human Serum Immunoglobulin A and Complement Component receptor 1 (C5aR1) to Chronic Obstructive Pulmonary, Asthma and Tonsillitis Diseases

Haneen S.  Albachary; Shaymaa  Raisan; Ziyad  Malgooth

doi:10.24126/jobrc.2022.16.1.626

Authors

Haneen S. Albachary
Shaymaa Raisan
Ziyad Malgooth

DOI:

https://doi.org/10.24126/jobrc.2022.16.1.626

Keywords:

Asthma, COPD, Tonsillitis, IgA, C5a, Component C5a R1 (C5aR1)

Abstract

Aim of the study: assess the level of immunoglobulin A, IgA, Complement protein C5a in Chronic Obstructive Pulmonary COPD, Asthmatic, and Tonsillitis patients.

Material and methods: 98 samples were collected from patients aged (5 years old to older than 45 years) of different sexes, as well as samples, collected from 10 healthy people as control group in an immunological study. Serum concentration was done according to human IgA Bioassay Technology Laboratory Enzyme-Linked Immunosorbent Assay (ELISA) - Kits Cat.No E0189Hu and Complement Component C5a R1 Enzyme-Linked Immunosorbent Assay (ELISA) Kit Cat. No. E6576Hu.

Results: of the current study showed that the concentration of antibody A (IgA >20ng/ml) was higher in males by (62.5%) compared to females and that the highest concentration was found in the age group greater than 45 by (31.8%) ) with a significant difference between the remaining age groups at the level of probability (p > 0.05) and concentration of antibody A (IgA >20ng/ml) was high in all patients, and asthma constituted the highest percentage of increase in antibody A concentration by (32.65%) compared to the control samples with the presence of Significant difference at the level of probability (p > 0.05). the study also showed that Complement Component C5a R1 was high in all disease cases, and the increase was equal in percentage (6.8%) for the distribution of concentrations on patient samples with a significant difference between healthy and sick patients at the level of probability (p > 0.05) and it was high in males only with a percentage of (23.8 and that). The highest concentration was found in the two age groups (5-14and44-35) with a percentage of (6.8%) with no significant difference between the remaining age groups at the level of probability (p > 0.05).

CONCLUSION:Asthma patients affected by the immune changes accompanying the disease compared to patients with Tonsillitis and COPD. High level of antibody concentration ,C5 in all diseased conditions, most affected by Asthmatic patients.