The Anti-bacterial activity for trimethoprim and its complexes

Submitting article

Abstract

Background: The biological assessment of trimethoprim organotin complexes is the subject
of the work discussed in this publication.
Objective: The purpose of this project is to investigate the properties of trimethoprim tin
complexes and via characterizing their IR and NMR elemental analysis sensitivity.
Material and methods: These complexes combine octahedral ML6 and pyramidal ML5 tin
complexes by allowing amino groups present in the medicinal ingredients to react with
organotin (IV).
Results: The complex conductivity was also determined for the prepared complexes and
displayed low values.
Discussions: Two concentrations of these complexes were screened for antibacterial activity
against Gram+ve (Bacillus Pumilus) and (Candida albicans) by the Agar diffusion disc
technique and showed a significant activity.
In conclusion: the synthesized compounds proven to be more effective in inhibiting bacteria
such as a) Bacillus Pumilus and b) Candida albicans at two concentrations (1×10-2, 1×10-
4M).