Study the toxic effect of non-bound colicins extracted from Escherichia coil on transplanted Murine adenocarcinoma (AM3)

Hind Hussein  Obaid; Nahiy Yousif  Yaseen; Rajwa Hassan  Essa

doi:10.24126/jobrc.2009.3.2.69

Study the toxic effect of non-bound colicins extracted from Escherichia coil on transplanted Murine adenocarcinoma (AM3)

Authors

Hind Hussein Obaid
Nahiy Yousif Yaseen
Rajwa Hassan Essa

DOI:

https://doi.org/10.24126/jobrc.2009.3.2.69

Keywords:

E.coli, colicins, cytotoxicity, murine adenocarcinoma

Abstract

Four types of non-bound colicins (H5, H9, H13, H19) extracted from intestinal normal flora E.coli isolated from apparently healthy people’s stool. Then cytotoxic effect of colicins on transplanted murine adenocarcinoma (AM3) was studied. The results showed,that the four colicins had inhibitory effects on growth of AM3 cells when injected intratumorally at (200) mg/kg. Percentages of tumor inhibition were (98.79, 90.45, 90.08 and 88.26) % for colicins (H19, H13, H9 and H5) respectively. Intraperitoneal injection caused less inhibition, (57.47, 36.25, 60.26 and 53.25) % respectively using a daily dose of (200) mg/kg for period of 24 days.

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Published

2009-06-01

How to Cite

Obaid, H. H. ., Yaseen, N. Y. ., & Essa, R. H. . (2009). Study the toxic effect of non-bound colicins extracted from Escherichia coil on transplanted Murine adenocarcinoma (AM3). Journal of Biotechnology Research Center, 3(2), 53–62. https://doi.org/10.24126/jobrc.2009.3.2.69

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Issue

Vol. 3 No. 2 (2009): Issue 2

Section

Research articles

License

This is an Open Access article distributed under the terms of the creative commons Attribution (CC BY) 4.0 license which permits unrestricted use, distribution, and reproduction in any medium or format, and to alter, transform, or build upon the material, including for commercial use, providing the original author is credited.