Dioxins and their effect on human toxicity

Abstract

Background: the interaction of human with dioxin and possible outcome from exposure to such compounds was reviewed. Red flag was raised to investigate these compound following media inquiries dealing with assassination of the Ukraine presidential candidate Victor Yushchenko using the most toxic dioxin, tetrachlorodibenzodioxin or TCDD.

Results: Human may be exposed to dioxins following environmental, occupational, or accidental pollutant that when enter the body they are either metabolized then eliminated with different capacity depending on individual’s physiology, health, does been administrated, or can be stored in body fat. Detoxification of dioxins occurs by microsomes enzymes that alter their structure by adding oxygen to lipophilic chemicals in the liver.

Conclusions: Dioxins exert carcinogenic action in human, and other morbidities such as atherosclerosis, hypertension, and diabetes, and with extend exposure they can disrupt nervous, immune, reproductive, and endocrine system. From the other hand, exposure to high doses within short time cause liver function impairment and chloracne. Deformed fetuses in many births were attributed to dioxins poisoning. Ramifications on health were documented through scientific reports placing dioxins of high toxicity to human.