Assessment of Estradiol and C-Reactive Protein in Menopause Women

Abstract

Background: A woman enters menopause when her menstrual cycles permanently cease. Estradiol has a significant impact on inflammatory and immunological functions. Objective: The purpose of this study was to compare menopausal women's levels of estradiol and inflammatory markers (C-reactive protein) to those of healthy women as a control group. Methodology: Samples were taken from female volunteers throughout a three-month period, and forty-five (45) menopausal women were compared with (45) healthy women as controls, whose ages ranged from 45 to 55. Results: There was a significant difference in BMI across the groups in this study (p = 0.039). Patient total cholesterol, triglyceride SBP, and DBP were significantly higher than those of controls (p<0.001), while HDL was significantly lower than that of controls (p = 0.011). Significant differences were observed in hormonal and inflammatory markers: estradiol (p≤0.001) and CRP (p≤0.001). Conclusion: A prominent indicator of early cardiovascular disease in menopausal women is dyslipidemia, elevated inflammatory markers (C-reactive protein), and decreased estrogen levels.